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QBiC study examines origin of diseases in newborns

QBiC study examines origin of diseases in newborns

Tribune News Network
Doha
TOUTED as the first of its kind in the Middle East region, the Qatari Birth Cohort (QBiC) study is currently being conducted by Qatar Biobank, part of Qatar Foundation Research, Development and Innovation. The uniqueness of this study comes from the environmental protocols that have been set up to understand gene-environment interactions associated with health impact.
A total of 216 pregnant women have been observed as part of Qatar’s first mother-childbirth cohort study to date. The study aims to examine how factors such as the environment, genetics, nutrition and social aspects may affect their baby’s health. Preliminary findings reveal that 70 percent of the women are overweight; 37 percent have gestational diabetes; 20 percent have a thyroid dysfunction; 10 percent have reported a psychological illness and nine percent are diagnosed with hypertension.
“No one has done this before in the region, specifically for birth cohort studies. There have been smaller studies completed or ongoing in the Middle East with a small number of participants, but nothing that is as holistic as ours,” said Dr Eleni Fthenou, a scientist at Qatar Biobank.
The QBiC study is now in its pilot phase and has recruited 216 pregnant women and 76 fathers-to-be. The study aims to recruit 3,000 families – mothers, fathers and children – and follow the journey of the child until they are five years old.
One of the main strengths of the study will be the large number of participants. The data collected from this large study sample will allow for research on multiple outcomes.
“Unlike other birth cohort studies in the Middle East region that are based on specific research hypothesis, the QBiC study will provide an excellent opportunity to address a broad range of research questions using innovative approaches. The project aims in-depth investigation of the impact of genome-exposure synergy in the establishment of adverse birth outcomes and chronic diseases development. And because of this, we can cover multiple outcomes,” said Dr Fthenou. The research team at Qatar Biobank has developed well-designed protocols for data collection with a focus on getting harmonised data for future collaborations with other international birth cohorts. And although there are multiple birth cohort studies in Europe, the United States or Australia, the Arab population is a minority in these studies.
Unfortunately, Arab genomes are severely under-represented in genomic studies globally but Qatar, through its various initiatives, is putting Arab genome on the map of genomic research and science, and therefore the QBiC study has a large Arab population sample.
“In the QBiC study, we have 31 nationalities at the moment. We recruit Qataris and long-term residents – those who have been living in Qatar for 15 years or more. Qataris represent 28 percent of the sample population, while long-term Arab residents are at 54 percent, and other nationalities stand at 18 percent,” according to Dr Fthenou.
While the QBiC study was ready to move to the second phase, the COVID-19 situation has caused a delay. In the second phase, the team is expected to collect data from newborns and toddlers, with mothers also being tracked with their babies in the first month after delivery.
“We will get data such as whether the mother is breastfeeding and what type of breastfeeding (exclusive or predominant); we will have the mother checked for postpartum depression; and follow-up on the baby at six months, one year, two years and finally at four years,” Dr Fthenou said.
All the collected data will be associated with multiple health outcomes at different time points. Dr Fthenou explained that it is a “unique epidemiological study that will allow us to assess how various types of environmental exposures co-exist. Novel tools and methods will be implemented to obtain estimates of individual environmental exposures, including outdoor and indoor air pollution”.

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