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Washington: US scientists announced on Wednesday they had created the first 3D atomic scale map of the part of the novel coronavirus that attaches to and infects human cells, a critical step toward developing vaccines and treatments.
The team from the University of Texas at Austin and the National Institutes of Health (NIH) first studied the genetic code of the virus made publicly available by Chinese researchers, and used it to develop a stabilised sample of a key part called the spike protein. They then imaged the spike protein using cutting-edge technology known as cryogenic electron microscopy, publishing their findings in the journal Science.
“The spike is really the antigen that we want to introduce into humans to prime their immune response to make antibodies against this, so that when they then see the actual virus, their immune systems are ready and loaded to attack,” UT Austin scientist Jason McLellan, who led the research, told AFP. Their engineered spike protein is itself being tested as a potential vaccine by the NIH. (AFP)
The team from the University of Texas at Austin and the National Institutes of Health (NIH) first studied the genetic code of the virus made publicly available by Chinese researchers, and used it to develop a stabilised sample of a key part called the spike protein. They then imaged the spike protein using cutting-edge technology known as cryogenic electron microscopy, publishing their findings in the journal Science.
“The spike is really the antigen that we want to introduce into humans to prime their immune response to make antibodies against this, so that when they then see the actual virus, their immune systems are ready and loaded to attack,” UT Austin scientist Jason McLellan, who led the research, told AFP. Their engineered spike protein is itself being tested as a potential vaccine by the NIH. (AFP)
